STUDY ON SYNTHESIS OF NANOGEL MATERIAL ENCAPSULATED CLOVE BUD EXTRACT (Syzygium aromaticum L.)
DOI:
https://doi.org/10.62985/j.huit_ojs.vol26.no3.435Keywords:
Nanogel, β-cyclodextrin, alginate, clove bud extractAbstract
Nanogels encapsulating clove bud extract were fabricated using β-cyclodextrin (CD) and alginate (alg) via electrostatic interactions between the Ca²⁺-crosslinked alginate matrix and CD. The structures of hollow nanogel (CD/alg) and nanogel carrying clove bud extract (DH@CD/alg) were analyzed by infrared spectroscopy. The morphology, particle size, dispersion in water and stability of nanogel with different clove bud extract ratios were analyzed by TEM, DLS and Zeta potential measurement techniques. Nanoparticles prepared under the optimal formulation conditions were predominantly spherical and exhibited a fairly uniform size distribution within the range of 40–100 nm. The nanogel dispersions showed high colloidal stability in aqueous solution, with zeta potential values ranging from -45.6 to -68.8 mV.
References
[1] I. Gülçin, M. Elmastaş, and H. Y. Aboul-Enein, “Antioxidant activity of clove oil: A powerful antioxidant source,” Arab. J. Chem., vol. 5, no. 4, pp. 489–499, 2012, doi: https://doi.org/10.1016/j.arabjc.2010.09.016
[2] P. K. Sofia, R. Prasad, V. K. Vijay, and A. K. Srivastava, “Evaluation of antibacterial activity of Indian spices against common foodborne pathogens,” Int. J. Food Sci. Technol., vol. 42, no. 8, pp. 910–915, 2007, doi: https://doi.org/10.1111/j.1365-2621.2006.01308.x
[3] Nguyen Cao Hien, Le Thi Thanh Van, Le Van Dung, Dang Chi Hien. “Chemical composition and activity of ethanol extract from clove buds (Syzygium aromaticum L.),” Tạp chí Phân tích Hóa, Lý và Sinh học, vol. 30, no. 3A, pp. 68–74, 2024.
[4] Cao-Hien Nguyen, Kien-Sam Banh, Chi-Hien Dang, Cong-Hao Nguyen, Thanh-Danh Nguyen, “β-Cyclodextrin/alginate nanoparticles encapsulated 5-fluorouracil as an effective and safe anticancer drug delivery system,” Arab. J. Chem., vol. 15, no. 6, Art. no. 103814, 2022, doi: https://doi.org/10.1016/j.arabjc.2022.103814
[5] S. Nazir, M. U. A. Khan, W. S. Al-Arjan, S. I. A. Razak, A. Javed, and M. R. A. Kadir, “Nanocomposite hydrogels for melanoma skin cancer care and treatment: In-vitro drug delivery, drug release kinetics and anti-cancer activities,” Arab. J. Chem., vol. 14, Art. no. 103120, 2021, doi: https://doi.org/10.1016/j.arabjc.2021.103120
[6] T.-D. Nguyen, T. H.-N. Tran, C.-H. Nguyen, C. Im, and C.-H. Dang, “Synthesis and characterization of β-cyclodextrin/alginate nanoparticle as a novel drug delivery system,” Chem. Biochem. Eng. Q., vol. 29, no. 3, pp. 429–435, 2015.
[7] T.-D. Nguyen, C.-H. Dang, and D.-T. Mai, “Biosynthesized AgNP capped on novel nanocomposite 2-hydroxypropyl-β-cyclodextrin/alginate as a catalyst for degradation of pollutants,” Carbohydr. Polym., vol. 197, pp. 29–37, 2018, doi: https://doi.org/10.1016/j.carbpol.2018.05.077
[8] T.-D. Nguyen, T.-T. Vo, T. T.-T. Huynh, C.-H. Nguyen, V.-D. Doan, D.-T. Nguyen, T.-D. Nguyen, and C.-H. Dang, “Effect of capping methods on the morphology of silver nanoparticles: Study on the media-induced release of silver from the nanocomposite β-cyclodextrin/alginate,” New J. Chem., vol. 43, pp. 16841–16852, 2019, doi: https://doi.org/10.1039/C9NJ04730A
[9] Nguyễn Cao Hiền, Tán Văn Hậu, Lê Thị Thanh Vân, Võ Tuấn Quốc, “Tổng hợp hệ nano hydroxypropyl-beta-cyclodextrin/alginate làm vật liệu mang thuốc,” Tạp chí Khoa học Công nghệ và Thực phẩm, vol. 13, no. 1, pp. 89–94, 2017.
